Ra Pharma received $58.5 million from a mix of strategic and VC investors to take on Alexion's intravenously infused orphan drug Soliris with a cheaper, subcutaneously delivered alternative.
"Cover all the bases" is the theme of FierceDrugDelivery's annual list of the top drug delivery partnerships. Finding 10 significant alliances that represent the full range of drug delivery advances was a challenge, and there are certainly other deals out there that are both novel and of high importance.
Still, the tie-ups highlighted here represent the arena's diversity on multiple levels. Half of the deals involve use of drug delivery devices like "smart" inhalers and drug-coated angioplasty balloons, while others focus on the molecular aspects, like transportation across biological barriers and the development of formulations that are efficacious and/or differentiate the medication.
We considered deals that commenced in 2014 and so far in 2015.
The Centers for Disease Control and Prevention says that a formulation of Endo's pain med, Opana ER--that's supposed to be difficult to crush--is responsible for an outbreak of HIV in southern Indiana, because the changes made it easier to prepare the drug for more dangerous intravenous or subcutaneous injection. Time reports that drug addicts prefer the formulation to heroin even though it is more expensive and doesn't last as long. HIV spread through the sharing of needles, resulting in at least 135 HIV infections in a rural Indiana county of 4,200 people. Read more >>
POPULAR COMMENT THREADS
Researchers at MIT and Massachusetts General Hospital have designed an expanding pill that can be easily swallowed but can remain in the stomach potentially for months without obstructing normal gastrointestinal function.
Israeli Parkinson's specialist Intec Pharma and drug delivery device maker EyeGate aim to debut on the Nasdaq this week for a combined $51 million.
Germany's leon-nanodrugs GmbH announced the closure of its €18.5 ($20.4 million) Series A preferred stock offering. The company develops oral and parenteral reformulations of generic active pharmaceutical ingredients using its patented MJR nanotechnology platform.
Folding DNA into new, functional shapes isn't a new technique, but researchers at Arizona State University have demonstrated novel design methods that allow them an amount of control over the genetic substance never seen before, creating new three-dimensional shapes that could ultimately be used in drug delivery.
RNAi specialist Alnylam initiated Phase I/II trials of its candidate to treat AAT deficiency-associated liver disease (alpha-1 liver disease).
Researchers at Washington University iin St. Louis and the University of Illinois at Urbana-Champaign have overcome a common problem in drug delivery to the brain, which is to get the therapies to target certain brain circuits without accidentally affecting other parts of the brain or body.
From Our Sister Sites
There's been lots of hullaballoo surrounding Sanofi and MannKind's launch of inhaled insulin Afrezza, but for the arrival of the pair's first DTC campaign? Not so much.
When India's Wockhardt acknowledged recently it was pulling all of the drugs still on the market that it had shipped before the FDA banned two of its plants, it didn't say what those numbers might add up to. Try more than 180 million bottles, cartons and pouches.