UPDATED: Cynapsus' sublingual Parkinson's med for 'off' episodes progresses to PhIII

Cynapsus kicked off patient enrollment in its Phase III clinical trial of sublingual apomorphine for Parkinson's patients who stop responding to levodopa.

Langer Lab company gets $5M in funding for drug-delivery device

Langer Lab startup SQZ Biotech raised $5 million in a Series A round led by Polaris Venture Partners to support its method to gain entry into a cell's membrane by first squeezing it through a device.

OptiNose heralds late-stage clinical success for nasal anti-inflammatory

Pennsylvania-based OptiNose, the creator of a bi-directional device for nasal medications, garnered positive results in a late-stage trial for its nasal polyp treatment. The company adds the anti-inflammatory treatment to its clinical lineup of migraine and autism candidates, both of which use the same delivery tech.

Singapore team develops slow-release hydrogel with hep C potential

Hydrogels are known to give drugs an edge when it comes to quick deliverability and simple application, but their long-term efficacy has come into question as their release rates are difficult to control. Researchers in Singapore have developed a new kind of hydrogel that prevents this premature release and allows for fewer doses in patients with chronic diseases like hepatitis C.

Alnylam's hemophilia candidate reduces levels of anticoagulant in PhI study

RNAi specialist Alnylam said that development of its early-stage subcutaneous compound for hemophilia and rare bleeding will be accelerated following ongoing Phase I trial results, which indicated that the candidate can knock down levels of the anticoagulant known as antithrombin by up to 86%. Pivotal trials for FDA approval are slated to begin in mid-2016.

FDA warns that transdermal patch for ADHD can lead to permanent skin discoloration

The FDA warned that a transdermal patch used to treat ADHD in children and adolescents can lead to chemical leukoderma, or permanent skin discoloration, as a result of the skin's repeated exposure to specific chemical compounds.

Harvard team makes 'sweating' vehicles for liquid drug delivery

Materials scientists are once again looking to nature to solve a drug delivery problem. This time, researchers from Harvard have investigated the way in which living tissues bring liquids where they're needed and ultimately secrete them--and they developed a synthetic system that mimics the process.

IPOs: Celyad rakes in $100M, Neos shoots for $69M

Two companies with a focus on drug delivery are making a go at an IPO, joining several biotechs that have thrown their hats in the ring in the last few days. Belgian gene therapy specialist Celyad--formerly Cardio3--has priced its offering on the Nasdaq for $100 million, and ADHD formulator Neos Therapeutics filed with the SEC to raise up to $69 million.

Bayer studies eye drug delivery in collaboration with Johns Hopkins

Bayer is collaborating with Johns Hopkins University's Wilmer Eye Institute to develop new forms of drug delivery to the back of the eye. Targeted diseases include age-related macular degeneration and diabetic macular edema, which both result in in vision loss.

Canadian team developing drug-delivering contact lens

A PhD candidate at Canada's McMaster University is developing a drug delivery contact lens for glaucoma patients because eye drops are incredibly inefficient and deliver only 5% of the active ingredient they carry to the cornea.

Acorda's inhaled levodopa shows promise in Phase II trials

Acorda Therapeutics moved a step closer to collecting the payoff from its $525 million acquisition of Civitas, maker of an inhaled levodopa, in the scramble to deliver an improved formulation of the standard Parkinson's med. The conventional oral formulation suffers from unpredictable absorption in the bloodstream and a wearing-off effect after about 5 years.

UPDATED: Microchips Biotech partners with Teva on wireless drug delivery, announces new CEO, raises $18M in financing

On the heels of Microchips Biotech's $35 million partnership with Teva to apply the company's electronic drug delivery implant for administration over months to years toward at least one disease area, the company announced that Cheryl Blanchard, the former chief scientific officer of Zimmer, will become its new CEO.

ADA: Nasal powder and artificial pancreas with glucagon both show potential

Two new studies presented at the annual American Diabetes Association have shown the benefits of the hormone glucagon--used to control the concentration of glucose in the bloodstream--in patients with Type 1 diabetes. One is a nasal powder to treat hypoglycemia in children and the other is an advance in the development of an effective artificial pancreas, finding the addition of glucagon could reduce nighttime hypoglycemia.

Study finds Novo's tablet for vaginal atrophy increases compliance compared to creams

A study found that tablets increase compliance among postmenopausal women suffering from vaginal atrophy when compared to cream. Almost 90% of patients who took the cream stopped using it after the first prescription, compared to 58% of patients who were on Novo Nordisk's Vagifem 10 milligram estradiol tablets.

WHO adds postpartum contraceptive ring to 2015 essential meds list

Bolstering recent growth in the research of progesterone-loaded intravaginal rings as contraceptives, the World Health Organization has voiced its approval, adding the delivery method to its 2015 essential medicines list, particularly for postpartum women and with a focus on the developing world.

Biotie nets $56M+ in IPO, fellow Parkinson's player Cynapsus up next, followed by Intec Pharma

It's been a busy week on Wall Street for Parkinson's players all over the globe. Finland's Biotie Therapies saw its stock surge upon debut on the Nasdaq, Canada's Cynapsus plans to hit the exchange this week, and Israel's Intec Pharma plans to conduct an IPO shortly.

Abuse of Endo's second-generation Opana ER formulation implicated in Indiana HIV epidemic

The Centers for Disease Control and Prevention says that a formulation of Endo's pain med, Opana ER--that's supposed to be difficult to crush--is responsible for an outbreak of HIV in southern Indiana, because the changes made it easier to prepare the drug for more dangerous intravenous or subcutaneous injection.

Oculus receives FDA clearance for novel, spray-based wound care formulation

Oculus Innovative Sciences announced that it has received FDA 510(k) clearance for its Alevicyn SG Antipruritic Spray Gel to treat dermatologic conditions like burning and itching skin, as well as skin irritation, lacerations, abrasions and minor burns.

Implanted device releases drugs to help determine cancer-killing course of action

Researchers from MIT demonstrated that a 3-mm-long microdevice holding up to 16 different drugs and drug combinations can release those drugs when implanted directly in a tumor to then determine the tumor's sensitivity to those therapies.

Research group seeks to promote crystals as drug delivery, development tools

Materials science is a crucial facet of the drug delivery realm, and researchers in the U.K. and Ireland are rallying to bring attention to the importance of crystallization as an important part of the future of drug development and delivery.