Scientists at the University of California, Davis, have successfully isolated the protein that allows a meningitis-causing fungus to cross the blood-brain barrier, a breakthrough that could lead to new treatments for the condition and other brain infections.
The blood-brain barrier is the body's way of keeping harmful substances away from the brain, but it's also a daunting obstacle for drug delivery experts looking to send treatments to the organ. Now, researchers at the Mayo Clinic have developed a synthetic peptide carrier to shuttle small molecules past the barrier and into the brain.
At the American Society for Microbiology's annual meeting this week, a team of researchers from the University of California, Davis, demonstrated a study showing that silicon nanoparticles they designed could penetrate the blood-brain barrier.
AstraZeneca's MedImmune forged a new deal with Bioasis Technologies, licensing from the Vancouver, Canada, company its brain delivery platform aimed at overcoming challenges associated with the blood-brain barrier.
To deliver large proteins past the blood-brain barrier for the treatment of Alzheimer's, researchers have developed a compound that acts as a molecular "crossing guard" for drugs to safely target brain cells and clear plaques believed to cause symptoms of the disease.
Researchers at the Karolinska Institutet in Sweden have shown that omega-3 fatty acids can cross the blood-brain barrier in a potential treatment for Alzheimer's disease.
In another successful breach of the blood-brain barrier, researchers have homed in on a nanovesicle drug capable of entering the brain and targeting tumor cells and blood vessels there.
Researchers in Finland have developed a way to penetrate the blood-brain barrier to treat schizophrenia, flooding it with high doses of the over-the-counter heartburn medicine famotidine.
Getting drugs into the brain is a bit of a holy grail, but researchers at Johns Hopkins University believe that they are a step closer with nanoparticles that can penetrate into the brain, potentially preventing recurrence of cancer after surgery by destroying any remaining tumor cells.
Researchers at the Harvard-affiliated McLean Hospital are taking a cue from the body's natural delivery method to get drugs across the blood-brain barrier.