A small patch that delivers DNA-loaded nanoparticles may be the next step in bone regeneration, offering a new option for patients currently receiving repeated, painful injections.
Researchers at the University of New South Wales have developed iron oxide nanoparticles capable of both delivering cancer drugs and precisely measuring their release in real time.
One of the more promising applications for stem cells has been in the field of regenerative medicine, but ensuring long-term survival of the cells after a transplant is difficult. Now, an international team of researchers has developed a delivery method by which to introduce several compounds that help the cells both survive and successfully differentiate in vivo.
Researchers at the Koch Institute of Integrative Cancer Research at MIT have developed layered nanoparticles with the cancer drug doxorubicin at the core, a second layer of gene-silencing interfering RNA and a final outer layer coated with tumor-targeting antigens.
A new study out of Oregon State University has shown that a combination of mild heat and nanoparticle-delivered chemotherapy can have a whopping effect on ovarian cancer cells that have otherwise built up a resistance to cancer drugs.
Researchers have come up with a novel way to treat damaged cartilage after a joint injury, using the friction produced by the active joint in combination with a nanoparticle-based hydrogel to release drugs when and where they will be most effective.
Nanoparticles for drug delivery have been designed with all sorts of practical shapes in mind, many of them offering a unique way to hold or release drugs, or to accurately target certain diseases. But researchers at Georgia Tech and other U.S. universities have found that nanoparticles shaped like discs are optimal for gaining entry into human cells.
Getting vaccines to stay in mucosal membranes long enough to trigger an immune response can be tricky. Engineers have now developed nanoparticles to carry vaccines to the mucosal surface in the lungs, protecting them long enough to provoke an immune response.
Diagnostics outfit Nanosphere hauled in $30.2 million in an over-allotted stock sale, padding its war chest as it develops tests using gold nanoparticle chemistry.
Researchers at McGill University in Montreal, Canada, have developed three-dimensional, nanosized cubes made of DNA that can be used to deliver drugs. It marks the first time molecules have been carried within DNA without being attached to the genetic material itself.