Research in drug delivery is shifting further and further to the nano scale, and while nanotechnology still hovers for the most part just short of the clinical stage, new techniques in manufacturing the particles are crucial to bringing them to the next step.
To tackle difficult-to-treat drug-resistant ovarian cancer, researchers at Tel Aviv University have developed nanoparticles designed to accumulate in clusters in tumors to deliver chemotherapy, increasing efficacy and reducing side effects.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have developed a light-activated delivery system for chemotherapy.
Researchers in China published an article in the journal Biomedical Materials demonstrating the drug-delivery potential of new gold nanoshells for cancer that also use hyperthermic effects to bring toxic cancer drugs to tumors with fewer side effects.
Scientists from Alnylam teamed with MIT researchers to develop a new nanoparticle platform with which to better deliver the genetic material to the liver. With MIT professor Robert Langer as one of its authors, the team published a paper in the journal Proceedings of the National Academy of Sciences highlighting its particles, which are inspired by the vehicles the body uses to transport cholesterol.
Patients with muscular dystrophy suffer from the dysfunction of the gene that produces dystrophin, which is a protein that maintains muscle cells' performance. And a team of researchers from Washington University School of Medicine in St. Louis has found that another factor might also play a role in the weakened muscles: The cells aren't properly recycling their waste.
MIT professor and entrepreneur Robert Langer is behind another innovative nanotechnology application for drug delivery, this time helping develop a model that could help researchers understand the way nanoparticles penetrate blood vessel walls.
A University of Rhode Island researcher won a National Institutes of Health grant of $1.3 million to further study the use of cancer-targeting copper sulfide nanoparticles for breast cancer.
High-density lipoproteins are a key component in the transportation of molecules such as cholesterol and fats inside the body. And by using a synthetic nanoparticle version of these natural vehicles, researchers have found a way to deliver drugs to the heart that could potentially prevent repeat heart attacks or stroke.
A nanoparticle with a specific code mechanism for release could allow drug-carrying vehicles to issue their payload upon contact with a specific biomarker. Now, researchers have developed a nanoparticle that uses coded DNA as this kind of "on-off" switch.