Finding the right delivery vehicle for a drug, one that will let the drug reach its full potential, is an invaluable prospect. And now MIT engineers have developed a way to test these vehicles quickly in vivo to determine which of them will be most efficient in delivering its payload.
A Purdue University team has created a new chip that promises to help test how cancer-killing nanoparticles react in a tumor environment. Because different nanoparticles perform vastly different functions in drug delivery, it's important to determine early on what kind of effect they will have on a tumor and what it would take to improve their outcome.
Combining chemotherapy and radiotherapy would be ideal for cancer treatment, but administering both at the same time can lead to unacceptable and often deadly levels of toxicity. Now researchers have developed liposomes that contain a chemotherapy drug activated by radiotherapy, offering both cancer-killing power and a targeted approach in a more controlled manner.
Creating the materials used for some of the most intricate nanostructures in drug delivery sometimes requires going back to the basics. In the case of researchers at the University of Oregon and the Berkeley Lab, this meant looking at the interaction between oil and water, developing nanosheets that could be used to compile delivery vehicles down the road.
Nanoparticles come in many shapes and sizes, each specifically designed to play a precise role in cancer treatment. And now, researchers from UC Davis have created nanotechnology with the ability to perform multiple tasks and the ultimate goal of destroying tumors.
Engineers and cell biologists have long used pulsed lasers to stimulate cells for gene transfection, drug injection or the regulation of gene expression. Now, Japanese scientists uncovered a new, potentially less-expensive method of delivering drugs and manipulating genes of individual cells by pairing nanosecond laser energy with carbon nanotubes.
Ophthalmology company Oraya Therapeutics will collaborate with researchers from Boston's Dana-Farber Cancer Institute to study applications of its novel radiation therapy against cancer when used in conjunction with gold nanoparticles.
Polymer nanomaterials are crucial for many types of drug delivery applications, offering the flexibility and durability needed to engineer specific shapes and sizes for particular delivery solutions. Now, at Carnegie Mellon, researchers have developed a new technique for creating self-assembling fibers for this purpose, taking a cue from the natural fibers in living cells.
A team of MIT researchers successfully tested a thin-film drug delivery system enabling steady, sustained release of medication for about 14 months, a scientific advancement with major commercial implications.
Like the tiny organelles used to propel some bacteria, artificial cilia developed by German engineers could someday help deliver drugs.